First, a few drops are injected (with a tiny needle) into the muscle that creates the wrinkle. When it is injected into a muscle, it blocks the nerve impulse from reaching that area, and as a result, the muscle weakens.
As the muscle weakens, the skin overlying the muscle relaxes and the wrinkles in the skin gradually soften and often disappear. If a specific muscle can't move, it can't cause a wrinkle.